LC3-mHTT-IN-AN1
CAS No. 486443-73-6
LC3-mHTT-IN-AN1 ( —— )
Catalog No. M21755 CAS No. 486443-73-6
LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 151 | In Stock |
|
5MG | 230 | In Stock |
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10MG | 340 | In Stock |
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25MG | 575 | In Stock |
|
50MG | 822 | In Stock |
|
100MG | 1107 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameLC3-mHTT-IN-AN1
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NoteResearch use only, not for human use.
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Brief DescriptionLC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
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DescriptionLC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
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Synonyms——
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PathwayAutophagy
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TargetAutophagy
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number486443-73-6
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Formula Weight411.04
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Molecular FormulaC15H9Br2NO3
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Purity>98% (HPLC)
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SolubilityDMSO : 125 mg/mL (304.11 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)
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SMILESBrC1=CC=C(C/2=C1)NC(C2=C/C3=CC(Br)=C(C(O)=C3)O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209.
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